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Article

23S rRNA 2058A-->G alteration mediates ketolide resistance in combination with deletion in L22.

Antimicrobial agents and chemotherapy - 1 Nov 2006

Berisio Rita, Corti Natascia, Pfister Peter, Yonath Ada, Böttger Erik C

Abstract excerpt

Resistance to macrolides and ketolides occurs mainly via alterations in RNA moieties of the drug-binding site. Using an A2058G mutant of Mycobacterium smegmatis, additional telithromycin resistance was acquired via deletion of 15 residues from protein L22. Molecular modeling, based on the crystal structure of the large ribosomal subunit from Deinococcus radiodurans complexed with telithromycin, shows that the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16923950
DOI: 10.1128/AAC.00767-06
PMCID: PMC1635173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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23S rRNA 2058A-->G alteration mediates ketolide resistance in combination with deletion in L22.PMID 16923950Read ↗

Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.Semantic proximity Read ↗

Macrolide resistance from the ribosome perspective.Semantic proximity Read ↗

The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel.Semantic proximity Read ↗

Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA.Semantic proximity Read ↗

L22 ribosomal protein and effect of its mutation on ribosome resistance to erythromycin.Semantic proximity Read ↗

23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.Semantic proximity Read ↗

Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.Semantic proximity Read ↗

Single and dual mutations at positions 2058, 2503 and 2504 of 23S rRNA and their relationship to resistance to antibiotics that target the large ribosomal subunit.Semantic proximity Read ↗

Noncanonical mutations in ribosome nascent peptide exit tunnel confer clarithromycin resistance in Mycobacterium abscessus complex.Semantic proximity Read ↗

A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre.Semantic proximity Read ↗

Erythromycin binding is reduced in ribosomes with conformational alterations in the 23 S rRNA peptidyl transferase loop.Semantic proximity Read ↗

Structural Insight into the Antibiotic Action of Telithromycin against Resistant MutantsSemantic proximity Read ↗

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