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Article

Impact of glutathione transferases genes polymorphisms in nevirapine adverse reactions: a possible role for GSTM1 in SJS/TEN susceptibility.

European journal of clinical pharmacology - 1 Oct 2017

Ciccacci Cinzia, Latini Andrea, Politi Cristina, Mancinelli Sandro, Marazzi Maria C, Novelli Giuseppe, Palombi Leonardo, Borgiani Paola

Abstract excerpt

PURPOSE: Nevirapine (NVP) is used in developing countries as first-line treatment of HIV infection. Unfortunately, its use is associated with common serious adverse drug reactions, such as liver toxicity and the most severe and rare Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). GSTT1 and GSTM1 genes code for enzymes involved in the metabolism of a wide range of drugs. We hypothesized that...

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Source

Identifiers

PMID: 28689274
DOI: 10.1007/s00228-017-2295-2

Genes

GSTM1
GSTT1

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