Article
A pharmacogenetics study in Mozambican patients treated with nevirapine: full resequencing of TRAF3IP2 gene shows a novel association with SJS/TEN susceptibility.
International journal of molecular sciences - 12 Mar 2015
Ciccacci Cinzia, Rufini Sara, Mancinelli Sandro, Buonomo Ersilia, Giardina Emiliano, Scarcella Paola, Marazzi Maria C, Novelli Giuseppe, Palombi Leonardo, Borgiani Paola
Abstract excerpt
Steven-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe adverse drug reactions, characterized by extensive epidermal detachment and erosions of mucous membrane. SJS/TEN is one of the most serious adverse reactions to Nevirapine (NVP) treatment, commonly used in developing countries as first-line treatment of human immunodeficiency virus infection. In the last years TRAF3IP2 gene variants had...
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