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Article

HCP5 genetic variant (RS3099844) contributes to Nevirapine-induced Stevens Johnsons Syndrome/Toxic Epidermal Necrolysis susceptibility in a population from Mozambique.

European journal of clinical pharmacology - 1 Mar 2014

Borgiani Paola, Di Fusco Davide, Erba Fulvio, Marazzi Maria C, Mancinelli Sandro, Novelli Giuseppe, Palombi Leonardo, Ciccacci Cinzia

Abstract excerpt

PURPOSE: Nevirapine (NVP) is an anti-retroviral drug used for the treatment of HIV infection, that may cause several severe adverse events, including Stevens Johnsons Syndrome/Toxic Epidermal Necrolysis (SJS/TEN). A recent whole genome association study highlighted a strong association with allopurinol-induced SJS/TEN within the HCP5 and PSORS1C1 genes in the Japanese population. Our aim was to verify the...

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PMID: 24322967
DOI: 10.1007/s00228-013-1622-5

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HCP5 genetic variant (RS3099844) contributes to Nevirapine-induced Stevens Johnsons Syndrome/Toxic Epidermal Necrolysis susceptibility in a population from Mozambique.PMID 24322967Read ↗

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