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Article

A genomic perspective on HLA evolution.

Immunogenetics - 1 Jan 2018

Meyer Diogo, C Aguiar Vitor R, Bitarello Bárbara D, C Brandt Débora Y, Nunes Kelly

Abstract excerpt

Several decades of research have convincingly shown that classical human leukocyte antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many questions remain regarding the type of selective regime acting on these loci, the time frame at which selection acts, and the functional connections between genetic variability and natural selection. In this review, we argue that genomic...

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Source

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Identifiers

PMID: 28687858
DOI: 10.1007/s00251-017-1017-3
PMCID: PMC5748415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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