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Article

Synaptic Deficits in Adnp-Mutant Mice Are Ameliorated by Histone Demethylase LSD1 Inhibition.

Autism research : official journal of the International Society for Autism Research - 1 Jul 2025

Lin Chih-Hung, Ren Yong, Tam Kin Wai, Conrow-Graham Megan, Yan Zhen

Abstract excerpt

ADNP (Activity-dependent neuroprotective protein) is a top-ranking autism risk gene. Here we examined synaptic alterations in heterozygous mice carrying an autism mutation on Adnp C-terminus (Adnpmut). We found that PFC pyramidal neurons in Adnpmut mice exhibited significantly diminished glutamatergic and GABAergic synaptic transmission, as indicated by markedly reduced excitatory postsynaptic currents (EPSC) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40536108
DOI: 10.1002/aur.70069
PMCID: PMC12257630

Genes

ADNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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