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Epigenetic treatment of synaptic and behavioral deficits in Dyrk1a-mutant mice.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2026

Lin Chih-Hung, Yu Mingjun, Patel Prachetas Jai, Li Pei, Yan Zhen

Abstract excerpt

Haploinsufficiency of Dyrk1a, which encodes the dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A), has been causally linked to autism. Here we examined transcriptomic, electrophysiological and behavioral alterations in mice carrying a loss-of-function mutation of Dyrk1a (Dyrkmut). We found that genes downregulated in prefrontal cortex (PFC) of male and female Dyrkmut mice were enriched in...

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Anxiety
Dyrk Kinases
Histone Demethylases
Prefrontal Cortex
Pyramidal Cells

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Social Behavior

Synaptic Transmission

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PMID: 41559452
DOI: 10.1038/s41386-026-02353-x
PMCID: PMC13291241

Genes

DYRK1A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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