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LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases

13 Aug 2021

Abstract excerpt

Learning and memory require structural and functional modifications of synaptic connections, and synaptic deficits are believed to underlie many brain disorders. The LIM-domain-containing protein kinases (LIMK1 and LIMK2) are key regulators of the actin cytoskeleton by affecting the actin-binding protein, cofilin. In addition, LIMK1 is implicated in the regulation of gene expression by interacting with the...

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PMID: 34440848
DOI: 10.3390/cells10082079

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