Article

DYRK1A up-regulation specifically impairs a presynaptic form of long-term potentiation

2019-05-22

Abstract excerpt

<h4>ABSTRACT</h4> Chromosome 21 DYRK1A kinase has long been associated with a variety of psychiatric diseases including Down Syndrome. We previously showed that Dyrk1A interacts with SWI/SNF (SWItch/Sucrose Non-Fermentable) nucleosome remodeling complex inducing expression changes of genes encoding key neuronal proteins. However, the functional impact of this kinase at the synapse level remains unclear. We studie...

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Literature Corpus work: a6580e5a-0488-5343-bf80-0e78dbfaebd0
DOI: 10.1101/645200

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