Article
RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning.
Proceedings of the National Academy of Sciences of the United States of America - 23 Sept 2008
Kaeser Pascal S, Kwon Hyung-Bae, Blundell Jacqueline, Chevaleyre Vivien, Morishita Wade, Malenka Robert C, Powell Craig M, Castillo Pablo E, Südhof Thomas C
Abstract excerpt
Activation of presynaptic cAMP-dependent protein kinase A (PKA) triggers presynaptic long-term plasticity in synapses such as cerebellar parallel fiber and hippocampal mossy fiber synapses. RIM1alpha, a large multidomain protein that forms a scaffold at the presynaptic active zone, is essential for presynaptic long-term plasticity in these synapses and is phosphorylated by PKA at serine-413. Previous studies...
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