Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The p27Kip1 tumor suppressor gene: Still a suspect or proven guilty?

Cancer cell - 1 Nov 2006

Polyak Kornelia

Abstract excerpt

The p27Kip1 cyclin-dependent kinase inhibitor is considered to be a tumor suppressor even though somatic mutations in p27Kip1 are only rarely detected in human tumors. On the other hand, overwhelming evidence indicates that its hemizygous or posttranscriptional loss plays an important role in tumorigenesis. Based on these data, p27Kip1 was classified as a haploinsufficient tumor suppressor whose protein level has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p27
Share to Genes, Tumor Suppressor
Share to Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiple Endocrine Neoplasia Type 1

Share to Neoplasms

Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Proteins

Source

Identifiers

PMID: 17097557
DOI: 10.1016/j.ccr.2006.10.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The p27Kip1 tumor suppressor gene: Still a suspect or proven guilty?PMID 17097557Read ↗

p27Kip1 and human cancers: A reappraisal of a still enigmatic protein.Semantic proximity Read ↗

The function of p27 KIP1 during tumor development.Semantic proximity Read ↗

Diverse Ways to Control p27Kip1 Function: miRNAs Come into PlaySemantic proximity Read ↗

Understanding p27<sup>kip1</sup>Deregulation in Cancer: Downregulation or Mislocalizaiton?Semantic proximity Read ↗

p27kip1: a target for tumor therapies?Semantic proximity Read ↗

The unpredictable consequences of CDKN1B/p27Kip1 mutations in cancer.Semantic proximity Read ↗

p27Kip1 and Tumors: Characterization of CDKN1B Variants Identified in MEN4 and Breast CancerSemantic proximity Read ↗

p27: tumor suppressor and oncogene ...?Semantic proximity Read ↗

[P27Kip1 is certainly a suppressor gene but with a dose effect].Semantic proximity Read ↗

p27kip1: A Multifunctional Cyclin-Dependent Kinase Inhibitor with Prognostic Significance in Human CancersSemantic proximity Read ↗

Regulation of the Cdk inhibitor p27 and its deregulation in cancerSemantic proximity Read ↗

Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.