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p27Kip1 and Tumors: Characterization of CDKN1B Variants Identified in MEN4 and Breast Cancer

26 Jan 2025

Abstract excerpt

p27Kip1 is a key cell cycle gatekeeper governing the timing of Cyclin-dependent kinase (CDK) activation/inactivation and, consequently, cell proliferation. Structurally, the protein is largely unfolded, a feature that strongly increases its plasticity and interactors and enhances the number of regulated cellular processes. p27Kip1, like other intrinsically unstructured proteins, is post-translationally modified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39936980
DOI: 10.3390/cells14030188

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