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Article

PI3K-Akt pathway enhances the differentiation of interleukin-27-induced type 1 regulatory T cells.

Immunology - 1 Nov 2017

Nadya Niken Adiba, Tezuka Hiroyuki, Ohteki Toshiaki, Matsuda Satoshi, Azuma Miyuki, Nagai Shigenori

Abstract excerpt

Interleukin 27 (IL-27) has been identified as a potent cytokine in the differentiation of type 1 regulatory T (Tr1) cells through interactions with several key elements, including transcription factors such as aryl hydrocarbon receptor and IL-21. Autocrine production of IL-21 is known to be important for maintaining IL-10 expression by Tr1 cells. Although previous studies have shown that the phosphoinositide...

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PMID: 28685820
DOI: 10.1111/imm.12789
PMCID: PMC5629445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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