Article
IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2009
Diveu Caroline, McGeachy Mandy J, Boniface Katia, Stumhofer Jason S, Sathe Manjiri, Joyce-Shaikh Barbara, Chen Yi, Tato Cristina M, McClanahan Terrill K, de Waal Malefyt René, Hunter Christopher A, Cua Daniel J, Kastelein Robert A
Abstract excerpt
IL-27 is secreted by APCs in response to inflammatory stimuli and exerts a proinflammatory Th1-enhancing activity but also has significant anti-inflammatory functions. We examined the molecular mechanism by which IL-27 regulates TGFbeta plus IL-6- or IL-23-dependent Th17 development in the mouse and human systems. IL-27 inhibited the production of IL-17A and IL-17F in naive T cells by suppressing, in a...
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