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Article

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 30 Dec 2008

Huber Magdalena, Brüstle Anne, Reinhard Katharina, Guralnik Anna, Walter Gina, Mahiny Azita, von Löw Eberhard, Lohoff Michael

Abstract excerpt

Differentiation of murine T-helper (Th) 17 cells is induced by antigenic stimulation and the sequential action of the cytokines IL-6, IL-21, and IL-23, along with TGFbeta. Current dogma proposes that IL-6 induces IL-21, which, in a STAT3-dependent manner, amplifies its own transcription, contributes to IL-17 production, and, moreover, promotes the expression of the IL-23 receptor. This, in turn, prepares cells...

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Identifiers

PMID: 19088203
DOI: 10.1073/pnas.0809077106
PMCID: PMC2634912

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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