Article
High-density Association Mapping and Interaction Analysis of PLA2R1 and HLA Regions with Idiopathic Membranous Nephropathy in Japanese.
Scientific reports - 9 Dec 2016
Thiri Myo, Honda Kenjiro, Kashiwase Koichi, Mabuchi Akihiko, Suzuki Hodaka, Watanabe Kimio, Nakayama Masaaki, Watanabe Tsuyoshi, Doi Kent, Tokunaga Katsushi, Noiri Eisei
Abstract excerpt
Although recent studies showed anti-PLA2R antibody plays a crucial role in idiopathic membranous nephropathy (IMN), detailed HLA mapping and interaction between the HLA genes and PLA2R1 have not been investigated in IMN. We genotyped across the PLA2R1 gene and the HLA region, using 183 IMN patients and 811 healthy controls. Five SNPs around the PLA2R1 gene were significantly associated with IMN. In addition to...
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