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Involvement of classic and alternative non-homologous end joining pathways in hematologic malignancies: targeting strategies for treatment

3 Nov 2021

Abstract excerpt

Chromosomal translocations are the main etiological factor of hematologic malignancies. These translocations are generally the consequence of aberrant DNA double-strand break (DSB) repair. DSBs arise either exogenously or endogenously in cells and are repaired by major pathways, including non-homologous end-joining (NHEJ), homologous recombination (HR), and other minor pathways such as alternative end-joining...

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PMID: 34732266
DOI: 10.1186/s40164-021-00242-1

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