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Pathways of DNA double-strand break repair and their impact on the prevention and formation of chromosomal aberrations

1 Jan 2004

Abstract excerpt

DNA double-strand breaks (DSB) are considered the critical primary lesion in the formation of chromosomal aberrations (CA). DSB occur spontaneously during the cell cycle and are induced by a variety of exogenous agents such as ionising radiation. To combat this potentially lethal damage, two related repair pathways, namely homologous recombination (HR) and non-homologous DNA end joining (NHEJ), have evolved, both...

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PMID: 15162009
DOI: 10.1159/000077460

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