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Article

CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer

5 Jul 2017

Abstract excerpt

BACKGROUND: DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E. coli AlkB homologs ALKBH2 and ALKBH3 have also been linked to direct reversal of alkylation damage. However, it is currently unknown whether ALKBH2 or ALKBH3 are found inactivated in...

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PMID: 28679371
DOI: 10.1186/s12885-017-3453-8

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