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Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation

29 Oct 2015

Abstract excerpt

BACKGROUND: Breast cancer formation is associated with frequent changes in DNA methylation but the extent of very early alterations in DNA methylation and the biological significance of cancer-associated epigenetic changes need further elucidation. METHODS: Pyrosequencing was done on bisulfite-treated DNA from formalin-fixed, paraffin-embedded sections containing invasive tumor and paired samples of...

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PMID: 26510686
DOI: 10.1186/s12885-015-1777-9

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