Article
DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines.
Molecular cancer - 25 Jan 2008
Roll J Devon, Rivenbark Ashley G, Jones Wendell D, Coleman William B
Abstract excerpt
BACKGROUND: DNA hypermethylation events and other epimutations occur in many neoplasms, producing gene expression changes that contribute to neoplastic transformation, tumorigenesis, and tumor behavior. Some human cancers exhibit a hypermethylator phenotype, characterized by concurrent DNA methylation-dependent silencing of multiple genes. To determine if a hypermethylation defect occurs in breast cancer, the...
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