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Article

Promoter Hypermethylation of the ATM Gene as a Novel Biomarker for Breast Cancer

26 Nov 2017

Abstract excerpt

Background: Breast cancer may be induced by activation of protooncogenes to oncogenes and in many cases inactivation of tumor suppressor genes. Ataxia telangiectasia mutated (ATM) is an important tumor suppressor gene which plays central roles in the maintenance of genomic integrity by activating cell cycle checkpoints and promoting repair of double-strand breaks of DNA. In breast cancer, decrease ATM expression...

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PMID: 29172272
DOI: 10.22034/apjcp.2017.18.11.3003

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