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Article

Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts.

DNA repair - 1 May 2012

Nay Stephanie L, Lee Dong-Hyun, Bates Steven E, O'Connor Timothy R

Abstract excerpt

Alkylating agents modify DNA and RNA forming adducts that disrupt replication and transcription, trigger cell cycle checkpoints and/or initiate apoptosis. If left unrepaired, some of the damage can be cytotoxic and/or mutagenic. In Escherichia coli, the alkylation repair protein B (AlkB) provides one form of resistance to alkylating agents by eliminating mainly 1-methyladenine and 3-methylcytosine, thereby...

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Identifiers

PMID: 22429847
DOI: 10.1016/j.dnarep.2012.02.005
PMCID: PMC3614354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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