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Article

Detection of Breast Cancer in Nipple Aspirate Fluid by CpG Island Hypermethylation

1 Jan 2004

Abstract excerpt

PURPOSE: New approaches to the early detection of breast cancer are urgently needed as there is more benefit to be realized from screening. Nipple aspiration is a noninvasive technique that yields fluid known to contain breast epithelial cells. Silencing of tumor suppressor genes such as p16(INk4a), BRCA1, and hMLH1 have established hypermethylation as a common mechanism for tumor suppressor inactivation in human...

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PMID: 14734448
DOI: 10.1158/1078-0432.ccr-0410-3

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