Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.

doi:10.1016/j.ymthe.2021.01.033

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Article

Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.

Molecular therapy : the journal of the American Society of Gene Therapy - 5 May 2021

Vidal René L, Sepulveda Denisse, Troncoso-Escudero Paulina, Garcia-Huerta Paula, Gonzalez Constanza, Plate Lars, Jerez Carolina, Canovas José, Rivera Claudia A, Castillo Valentina, Cisternas Marisol, Leal Sirley, Martinez Alexis, Grandjean Julia, Sonia Donzelli, Lashuel Hilal A, Martin Alberto J M, Latapiat Veronica, Matus Soledad, Sardi S Pablo, Wiseman R Luke, Hetz Claudio

Abstract excerpt

Alteration to endoplasmic reticulum (ER) proteostasis is observed in a variety of neurodegenerative diseases associated with abnormal protein aggregation. Activation of the unfolded protein response (UPR) enables an adaptive reaction to recover ER proteostasis and cell function. The UPR is initiated by specialized stress sensors that engage gene expression programs through the concerted action of the...

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Identifiers

PMID: 33545358
DOI: 10.1016/j.ymthe.2021.01.033
PMCID: PMC8116614

Genes

ATF4
ATF6

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