Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 7 May 2016

Kasza Ágnes, Hunya Ákos, Frank Zsuzsa, Fülöp Ferenc, Török Zsolt, Balogh Gábor, Sántha Miklós, Bálind Árpád, Bernáth Sándor, Blundell Katie L I M, Prodromou Chrisostomos, Horváth Ibolya, Zeiler Hans-Joachim, Hooper Philip L, Vigh László, Penke Botond

Abstract excerpt

Heat shock proteins (Hsps) have chaperone activity and play a pivotal role in the homeostasis of proteins by preventing misfolding, by clearing aggregated and damaged proteins from cells, and by maintaining proteins in an active state. Alzheimer's disease (AD) is thought to be caused by amyloid-β peptide that triggers tau hyperphosphorylation, which is neurotoxic. Although proteostasis capacity declines with age...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Dendritic Spines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heat-Shock Proteins

Share to Maze Learning

Share to Neuroblastoma

Share to Neuroprotective Agents

Share to Presenilin-1

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27163800
DOI: 10.3233/JAD-150860
PMCID: PMC4969717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease.PMID 27163800Read ↗

Translational Shift of HSP90 as a Novel Therapeutic Target from Cancer to Neurodegenerative Disorders: An Emerging Trend in the Cure of Alzheimer's and Parkinson's DiseasesSemantic proximity Read ↗

The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by which LA1011 may Improve the Prognosis of Alzheimer’s DiseaseSemantic proximity Read ↗

Molecular Mechanisms Underlying Neuroprotective Effect of Intranasal Administration of Human Hsp70 in Mouse Model of Alzheimer's Disease.Semantic proximity Read ↗

Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylationSemantic proximity Read ↗

Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesisSemantic proximity Read ↗

The induction of heat shock proteins as a potential strategy to treat neurodegenerative disordersSemantic proximity Read ↗

Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic InterventionSemantic proximity Read ↗

Profiling the Hsp70 Chaperone Network in Heat-Induced Proteotoxic Stress Models of Human NeuronsSemantic proximity Read ↗

Induction of Molecular Chaperones as a Therapeutic Strategy for the Polyglutamine DiseasesSemantic proximity Read ↗

Alzheimer's Disease and Molecular Chaperones: Current Knowledge and the Future of ChaperonotherapySemantic proximity Read ↗

Reversal of cognitive deficits in FUSR521G amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein inductionSemantic proximity Read ↗

Cellular DNAJBs are selectively associated with proteotoxic stress and underlying mechanisms in neurodegenerative conditionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.