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Article

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2007

Luo Wenjie, Dou Fei, Rodina Anna, Chip Sophorn, Kim Joungnam, Zhao Qi, Moulick Kamalika, Aguirre Julia, Wu Nian, Greengard Paul, Chiosis Gabriela

Abstract excerpt

Neurodegeneration, a result of multiple dysregulatory events, is a lengthy multistep process manifested by accrual of mutant variants and abnormal expression, posttranslational modification, and processing of certain proteins. Accumulation of these dysregulated processes requires a mechanism that maintains their functional stability and allows the evolution of the neurodegenerative phenotype. In malignant cells,...

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Identifiers

PMID: 17517623
DOI: 10.1073/pnas.0701055104
PMCID: PMC1890525

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