Article
The isolated major histocompatibility complex class I alpha3 domain binds beta2m and CD8alphaalpha dimers.
Molecular immunology - 1 Jan 2000
Whitman M C, Strohmaier J, O'Boyle K, Tingem J M, Wilkinson Y, Goldstein J, Chen T, Brorson K, Brunswick M, Kozlowski S
Abstract excerpt
The MHC class I molecule plays a crucial role in cytotoxic lymphocyte function. The heavy chain of the MHC class I molecule can form many non-covalent interactions with other molecules on multiple domains and surfaces. We have generated an isolated alpha3 domain of a murine MHC class I molecule and evaluated the contribution of this domain to binding with the MHC class I light chain, beta2m, and CD8. The alpha3...
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