Article
Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypes.
Molecular autism - 1 Jan 2017
Allemang-Grand Rylan, Ellegood Jacob, Spencer Noakes Leigh, Ruston Julie, Justice Monica, Nieman Brian J, Lerch Jason P
Abstract excerpt
BACKGROUND: Rett syndrome (RTT) is a neurodevelopmental disorder that predominantly affects girls. The majority of RTT cases are caused by de novo mutations in methyl-CpG-binding protein 2 (MECP2), and several mouse models have been created to further understand the disorder. In the current literature, many studies have focused their analyses on the behavioral abnormalities and cellular and molecular impairments...
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