White Matter Structural and Network Topological Changes Underlying the Behavioral Phenotype of MECP2 Mutant Monkeys.

doi:10.1093/cercor/bhab166

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

White Matter Structural and Network Topological Changes Underlying the Behavioral Phenotype of MECP2 Mutant Monkeys.

Cerebral cortex (New York, N.Y. : 1991) - 22 Oct 2021

Wang Jiaojian, Wang Zhengbo, Zhang Hongjiang, Feng Shufei, Lu Yi, Wang Shuang, Wang Hong, Sun Yi Eve, Chen Yongchang

Abstract excerpt

To explore the brain structural basis underlying the behavioral abnormalities associated with Rett syndrome (RTT), we carried out detailed longitudinal noninvasive magnetic resonance imaging analyses of RTT monkey models created by gene-editing, from weaning, through adolescence, till sexual maturation. Here, we report abnormal developmental dynamics of brain white matter (WM) microstructures and network...

Topics

Animals
Brain
Diffusion Tensor Imaging
Haplorhini
Phenotype
White Matter

Source

Open in PubMed

Identifiers

PMID: 34117744
DOI: 10.1093/cercor/bhab166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics