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Article

The status of pulmonary fibrosis in systemic sclerosis is associated with IRF5, STAT4, IRAK1, and CTGF polymorphisms.

Rheumatology international - 1 Aug 2017

Zhao Wenjie, Yue Xiaoyang, Liu Kuai, Zheng Junfeng, Huang Runda, Zou Jun, Riemekasten Gabriela, Petersen Frank, Yu Xinhua

Abstract excerpt

Pulmonary fibrosis (PF) is one of the leading causes of death in systemic sclerosis (SSc) patients. Although all SSc patients are characterized by autoimmunity, only part of them suffer from PF, suggesting that beside autoimmunity, some additional factors are involved in the initiation of PF in SSc. In this study, we aimed to identify genetic polymorphisms associated with the status of PF in SSc. We performed...

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Source

Identifiers

PMID: 28434122
DOI: 10.1007/s00296-017-3722-5

Genes

IRAK1
STAT4
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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