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Article

Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk.

Annals of the rheumatic diseases - 1 Apr 2018

Moreno-Moral Aida, Bagnati Marta, Koturan Surya, Ko Jeong-Hun, Fonseca Carmen, Harmston Nathan, Game Laurence, Martin Javier, Ong Voon, Abraham David J, Denton Christopher P, Behmoaras Jacques, Petretto Enrico

Abstract excerpt

OBJECTIVES: Several common and rare risk variants have been reported for systemic sclerosis (SSc), but the effector cell(s) mediating the function of these genetic variants remains to be elucidated. While innate immune cells have been proposed as the critical targets to interfere with the disease process underlying SSc, no studies have comprehensively established their effector role. Here we investigated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Scleroderma, Systemic

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Source

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Identifiers

PMID: 29348297
DOI: 10.1136/annrheumdis-2017-212454
PMCID: PMC5890626

Genes

GSDMA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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