Article
Major Histocompatibility Complex Class II Alleles Influence Induction of Pathogenic Antiphospholipid Antibodies in a Mouse Model of Thrombosis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Oct 2017
Papalardo Elizabeth, Romay-Penabad Zurina, Willis Rohan, Christadoss Premkumar, Carrera-Marin Ana Laura, Reyes-Maldonado Elba, Rudrangi Rajani, Alfieri-Papalardo Silvana, Garcia-Latorre Ethel, Blank Miri, Pierangeli Silvia, Brasier Allan R, Gonzalez Emilio B
Abstract excerpt
OBJECTIVE: Both environmental and genetic factors are important in the development of antiphospholipid antibodies (aPL) in patients with antiphospholipid syndrome (APS). Currently, the only available data on predisposing genetic factors have been obtained from epidemiologic studies, without mechanistic evidence. Therefore, we studied the influence of major histocompatibility complex (MHC) class II alleles on the...
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