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Environmental Triggers of Autoreactive Responses: Induction of Antiphospholipid Antibody Formation

10 Jul 2019

Abstract excerpt

Antiphospholipid antibodies (aPLs) comprise a diverse family of autoantibodies targeted against proteins with the affinity toward negatively charged phospholipids or protein-phospholipid complexes. Their clinical significance, including prothrombotic potential of anti-cardiolipin antibodies (aCLs), anti-β2-glycoprotein I antibodies (aβ2-GPIs), and lupus anti-coagulant (LA), is well-established. However, the...

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PMID: 31354742
DOI: 10.3389/fimmu.2019.01609

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