Article
Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotype.
Transfusion - 1 Nov 2004
Sayeh Ebrahim, Aslam Rukshana, Speck Edwin R, Le-Tien Hoang, Lazarus Alan H, Freedman John, Semple John W
Abstract excerpt
BACKGROUND: Immunoglobulin G (IgG) anti-platelet (PLT) immunity has been shown to be initiated by indirect allorecognition where recipient T cells recognize donor PLT antigens presented by class II molecules encoded by the major histocompatibility complex (MHC) on recipient antigen-presenting cells. To understand how the recipient's MHC class II molecules may influence PLT alloimmunity, immune responsiveness...
Topics
- Animals
- Blood Platelets
- CD8 Antigens
- Female
- Histocompatibility Antigens Class II
- Immunoglobulin G
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Knockout
- Phenotype
- Platelet Transfusion
- Transplantation, Homologous