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Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo

24 Jul 2009

Abstract excerpt

Antiphospholipid (aPL) antibodies recognize receptor-bound beta(2) glycoprotein I (beta(2)GPI) on target cells, and induce an intracellular signaling and a procoagulant/proinflammatory phenotype that leads to thrombosis. Evidence indicates that annexin A2 (A2), a receptor for tissue plasminogen activator and plasminogen, binds beta(2)GPI on target cells. However, whether A2 mediates pathogenic effects of aPL...

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PMID: 19628708
DOI: 10.1182/blood-2008-11-188698

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