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In Vivo Models of Thrombosis for the Antiphospholipid Syndrome

1 Oct 1996

Abstract excerpt

Utilizing this unique animal model of thrombosis we demonstrated that human (IgG, IgM or IgA) polyclonal and monoclonal antiphospholipid antibodies derived from APS patients have a significant enhancing effect on thrombus formation. This effect is reversed by treatment of the mice with hydroxychloroquine (plaquenil). In addition murine polyclonal and monoclonal anticardiolipin antibodies induced by active...

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PMID: 8902780
DOI: 10.1177/096120339600500524

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