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Article

Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer

30 Jun 2017

Abstract excerpt

Clinical challenges exist in reducing prostate cancer (PCa) disparities. The RNA splicing landscape of PCa across racial populations has not been fully explored as a potential molecular mechanism contributing to race-related tumour aggressiveness. Here, we identify novel genome-wide, race-specific RNA splicing events as critical drivers of PCa aggressiveness and therapeutic resistance in African American (AA)...

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PMID: 28665395
DOI: 10.1038/ncomms15921

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