Article

Integrated proteogenomics uncovers ancestry-specific and shared molecular drivers in localized prostate cancer

2025-11-29

Abstract excerpt

<h4>SUMMARY</h4> Our integrative proteogenomics (genome, proteome and phosphoproteome) of localized prostate cancer (PCa) in an equal-access Military Health System patient cohort (57 Black and 55 White) revealed significant ancestry-associated differences. Somatic and germline regulatory differences converged on androgen, metabolic, PI3K/AKT/mTOR, and DNA damage response (DDR) pathways, with ancestry-specific imm...

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Literature Corpus work: 3d186ca6-b36e-5737-9cf2-1ae4c297d9d8
DOI: 10.1101/2025.11.28.691220

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