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Article

Racial variation in the advanced prostate cancer genome.

Prostate cancer and prostatic diseases - 1 Dec 2025

Feng Emily M, Vo-Phamhi Jenny, Subramanian Aishwarya N, Dias Mikhail, Foye Adam, Vinson Jake, Hong Julian C, Freedland Stephen J, Alumkal Joshi J, Beltran Himisha, Morrissey Colm, Nelson Peter S, Chinnaiyan Arul M, Aggarwal Rahul, Small Eric J, Quigley David A, Sjöström Martin, Zhao Shuang G, Chen William S

Abstract excerpt

BACKGROUND: Racial differences in metastatic castration-resistant prostate cancer (mCRPC) genomes have not yet been fully studied. We aimed to investigate transcriptomic, mutational, and clinical differences by race in a large multi-institutional cohort of men with mCRPC. METHODS: Genomic and clinicopathologic data from four mCRPC tumor biopsy cohorts were obtained and aggregated. Gene set enrichment analyses...

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Identifiers

PMID: 40164700
DOI: 10.1038/s41391-025-00949-w
PMCID: PMC12643939

Genes

ERG
TMPRSS2
MYC
STAT3

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