Article
Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry.
PLoS genetics - 1 Feb 2020
Yuan Jiao, Kensler Kevin H, Hu Zhongyi, Zhang Youyou, Zhang Tianli, Jiang Junjie, Xu Mu, Pan Yutian, Long Meixiao, Montone Kathleen T, Tanyi Janos L, Fan Yi, Zhang Rugang, Hu Xiaowen, Rebbeck Timothy R, Zhang Lin
Abstract excerpt
Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence and worse survival than men of predominantly European Ancestry (EA). While socioeconomic factors drive this disparity, genomic factors may also contribute to differences in the incidence and mortality rates. To compare the prevalence of prostate tumor genomic alterations and transcriptomic profiles by patient genetic ancestry,...
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