Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs.

doi:10.1186/s13073-020-00778-7

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Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs.

Genome medicine - 28 Sept 2020

Castellani Christina A, Longchamps Ryan J, Sumpter Jason A, Newcomb Charles E, Lane John A, Grove Megan L, Bressler Jan, Brody Jennifer A, Floyd James S, Bartz Traci M, Taylor Kent D, Wang Penglong, Tin Adrienne, Coresh Josef, Pankow James S, Fornage Myriam, Guallar Eliseo, O'Rourke Brian, Pankratz Nathan, Liu Chunyu, Levy Daniel, Sotoodehnia Nona, Boerwinkle Eric, Arking Dan E

Abstract excerpt

BACKGROUND: Mitochondrial DNA copy number (mtDNA-CN) has been associated with a variety of aging-related diseases, including all-cause mortality. However, the mechanism by which mtDNA-CN influences disease is not currently understood. One such mechanism may be through regulation of nuclear gene expression via the modification of nuclear DNA (nDNA) methylation. METHODS: To investigate this hypothesis, we assessed...

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Identifiers

PMID: 32988399
DOI: 10.1186/s13073-020-00778-7
PMCID: PMC7523322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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