Article

Mitochondrial DNA Copy Number (mtDNA-CN) Can Influence Mortality and Cardiovascular Disease via Methylation of Nuclear DNA CpGs

2019-06-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Mitochondrial DNA copy number (mtDNA-CN) has been associated with a variety of aging-related diseases, including all-cause mortality. However, the mechanism by which mtDNA-CN influences disease is not currently understood. One such mechanism may be through regulation of nuclear gene expression via the modification of nuclear DNA (nDNA) methylation. <h4>Methods</h4> To inves...

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Literature Corpus work: e20157b0-a05d-5f07-a89e-43903ebdccfd
DOI: 10.1101/673293

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