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Smooth Muscle Cells Derived From Second Heart Field and Cardiac Neural Crest Reside in Spatially Distinct Domains in the Media of the Ascending Aorta-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2017

Sawada Hisashi, Rateri Debra L, Moorleghen Jessica J, Majesky Mark W, Daugherty Alan

Abstract excerpt

OBJECTIVE: Smooth muscle cells (SMCs) of the proximal thoracic aorta are embryonically derived from the second heart field (SHF) and cardiac neural crest (CNC). However, distributions of these embryonic origins are not fully defined. The regional distribution of SMCs of different origins is speculated to cause region-specific aortopathies. Therefore, the aim of this study was to determine the distribution of SMCs...

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Identifiers

PMID: 28663257
DOI: 10.1161/ATVBAHA.117.309599
PMCID: PMC5570666

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SHF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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