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Article

Embryologic Origin Influences Smooth Muscle Cell Phenotypic Modulation Signatures in Murine Marfan Syndrome Aortic Aneurysm

7 Jul 2022

Abstract excerpt

Background: Aortic root smooth muscle cells (SMC) develop from both the second heart field (SHF) and neural crest. Disparate responses to disease-causing Fbn1 variants by these lineages are proposed to promote focal aortic root aneurysm formation in Marfan syndrome (MFS), but lineage-stratified SMC analysis in vivo is lacking. Methods: We generated SHF lineage-traced MFS mice and performed integrated multiomic...

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PMID: 35861960
DOI: 10.1161/atvbaha.122.317381

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