Article

Detection of Kinase Domain Mutations in BCR-ABL1 Leukemia by Ultra-deep Sequencing of Genomic DNA

2022-03-16

Abstract excerpt

The screening of the BCR-ABL1 kinase domain (KD) mutation has become a routine analysis in case of warning/failure for chronic myeloid leukemia (CML) and B-cell precursor acute lymphoblastic leukemia (ALL) Philadelphia (Ph)-positive patients. In this study, we present a novel DNA-based next-generation sequencing (NGS) methodology for KD ABL1 mutation detection and monitoring with a 10 − 4 sensitivity. This approac...

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Literature Corpus work: d5151c05-c3cd-5827-9521-353e29117c32
DOI: 10.21203/rs.3.rs-1388992/v1

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