Article
Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA.
Scientific reports - 29 Jul 2022
Sánchez Ricardo, Dorado Sara, Ruíz-Heredia Yanira, Martín-Muñoz Alejandro, Rosa-Rosa Juan Manuel, Ribera Jordi, García Olga, Jimenez-Ubieto Ana, Carreño-Tarragona Gonzalo, Linares María, Rufián Laura, Juárez Alexandra, Carrillo Jaime, Espino María José, Cáceres Mercedes, Expósito Sara, Cuevas Beatriz, Vanegas Raúl, Casado Luis Felipe, Torrent Anna, Zamora Lurdes, Mercadal Santiago, Coll Rosa, Cervera Marta, Morgades Mireia, Hernández-Rivas José Ángel, Bravo Pilar, Serí Cristina, Anguita Eduardo, Barragán Eva, Sargas Claudia, Ferrer-Marín Francisca, Sánchez-Calero Jorge, Sevilla Julián, Ruíz Elena, Villalón Lucía, Del Mar Herráez María, Riaza Rosalía, Magro Elena, Steegman Juan Luis, Wang Chongwu, de Toledo Paula, García-Gutiérrez Valentín, Ayala Rosa, Ribera Josep-Maria, Barrio Santiago, Martínez-López Joaquín
Abstract excerpt
The screening of the BCR::ABL1 kinase domain (KD) mutation has become a routine analysis in case of warning/failure for chronic myeloid leukemia (CML) and B-cell precursor acute lymphoblastic leukemia (ALL) Philadelphia (Ph)-positive patients. In this study, we present a novel DNA-based next-generation sequencing (NGS) methodology for KD ABL1 mutation detection and monitoring with a 1.0E-4 sensitivity. This...
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