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Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Apr 2015

Yang Jun J, Landier Wendy, Yang Wenjian, Liu Chengcheng, Hageman Lindsey, Cheng Cheng, Pei Deqing, Chen Yanjun, Crews Kristine R, Kornegay Nancy, Wong F Lennie, Evans William E, Pui Ching-Hon, Bhatia Smita, Relling Mary V

Abstract excerpt

PURPOSE: Mercaptopurine (MP) is the mainstay of curative therapy for acute lymphoblastic leukemia (ALL). We performed a genome-wide association study (GWAS) to identify comprehensively the genetic basis of MP intolerance in children with ALL. PATIENTS AND METHODS: The discovery GWAS and replication cohorts included 657 and 371 children from two prospective clinical trials. MP dose intensity was a marker for drug...

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Identifiers

PMID: 25624441
DOI: 10.1200/JCO.2014.59.4671
PMCID: PMC4375304

Genes

NUDT15
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.PMID 25624441Read ↗

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