Recurrent and functional regulatory mutations in breast cancer.

doi:10.1038/nature22992

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Article

Recurrent and functional regulatory mutations in breast cancer.

Nature - 6 Jul 2017

Rheinbay Esther, Parasuraman Prasanna, Grimsby Jonna, Tiao Grace, Engreitz Jesse M, Kim Jaegil, Lawrence Michael S, Taylor-Weiner Amaro, Rodriguez-Cuevas Sergio, Rosenberg Mara, Hess Julian, Stewart Chip, Maruvka Yosef E, Stojanov Petar, Cortes Maria L, Seepo Sara, Cibulskis Carrie, Tracy Adam, Pugh Trevor J, Lee Jesse, Zheng Zongli, Ellisen Leif W, Iafrate A John, Boehm Jesse S, Gabriel Stacey B, Meyerson Matthew, Golub Todd R, Baselga Jose, Hidalgo-Miranda Alfredo, Shioda Toshi, Bernards Andre, Lander Eric S, Getz Gad

Abstract excerpt

Genomic analysis of tumours has led to the identification of hundreds of cancer genes on the basis of the presence of mutations in protein-coding regions. By contrast, much less is known about cancer-causing mutations in non-coding regions. Here we perform deep sequencing in 360 primary breast cancers and develop computational methods to identify significantly mutated promoters. Clear signals are found in the...

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PMID: 28658208
DOI: 10.1038/nature22992
PMCID: PMC5563978

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FOXA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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