Article
Sensitive detection of somatic mutations in GC-rich cancer gene promoters.
NAR cancer - 1 Jun 2026
Qi Meifang, Dave Preshita Sanjay, Francis Nicole, DeFelice Matthew, Pollock Sam, Corbitt Holly, Mitsiades Irene Rin, Wang Gengchao, Frere Paul, Fox Alan, Khitrov Gregory, Petersen Caroline, Larkin Katie, Hamilton Susanna, Ellisen Leif W, Gulhan Doga C, Hidalgo-Miranda Alfredo, Lennon Niall, Cibulskis Carrie, Rheinbay Esther
Abstract excerpt
Somatic mutations in protein-coding genes and noncoding regulatory regions are the major drivers of cancer. Only a relatively small number of somatic noncoding mutations that are likely drivers have been described to date, including those in the promoters of the TERT, FOXA1, and TP53 genes. The impact of these alterations can be profound by initiating, increasing, or abolishing gene expression. Promoter mutations...
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